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Latest Research News

Here we aim to bring you research news from around the world so you are always kept up to date.

A second UK clinical trial launches for patients with Rett Syndrome age 4-18. Please read this post for more information.

RETT_ARCH_RGBGW Research initiates a clinical trial of cannabidiol (CBD, GWP42003-P) in Rett syndrome in May 2019.

GWP42003-P (cannabidiol) is believe to affect several pharmacological pathways and may have the potential to modulate some of the pathophysiological mechanisms thought to underlie the neurobehavioral deficits present in Rett syndrome including excitatory/inhibitory neuronal imbalance, neuroinflammation and antioxidant dysfunction.

The aim of the clinical trial is to evaluate the safety and efficacy of GWP42003-P in reducing symptom severity in females, aged 4 to 18 years, with Rett syndrome. Symptom severity will be evaluated using caregiver and clinician measures that assess multiple symptoms and therefore reflect the overall condition.

Measuring changes in seizures frequency or severity is not, per se, a key objective of the trial. Several safety outcomes such as side effects, vital signs, lab assessments and tests will be analysed.

The effect of two doses will be compared with a placebo control across a 24-week treatment period. Patients completing the study will have the opportunity to take part in a 6-month extension study where all patients will receive GWP42003-P. In total, approximately 252 patients are expected to be included.

One of the eligibility requirements is for patients to refrain from taking medicinal cannabis, cannabinoid-based medications or cannabidiol oral solutions for at least 3 months prior to screening in the study. The full list of eligibility criteria can be found on [ Identifier: NCT03848832].

US trial sites in Cincinnati, OH and Greenwood, SC are now recruiting.

UK trial sites in Liverpool and London are expected to open in June and July 2019 respectively

For further information, please contact Reverse Rett:
Tel: 0161 434 8117

Further US sites are expected to open from June 2019 onwards in Nashville, TN; Houston, TX; Chicago, IL; San Diego, CA; Birmingham, AL; Philadelphia, PA; Boston, MA; St Paul, MN; Aurora, CO; Baltimore, MD; New York, NY; St Louis, MO.
GW is looking forward to working with the Rett Community on this important study investigating the safety and efficacy of GWP42003-P in people with Rett Syndrome.
©2019 GW Research Limited. All Rights Reserved.

Phase 2 Trial for Anavex 2-73 funded by RettSyndrome.Org March 2019

Ketamine clinical trials – funded by Rett Syndrome Research Trust February 2019

First UK clinical trial for Rett syndrome in the UK Sarizotan updated February 2019 – Enrolment completed and results expected late 2019.

Bridging the Divide – developing a mini gene, Dr Adrian Bird October 2017

Update on Trofinetide – Phase 3 Clinical Trials  October 2017

Development_of_the_Tailored_Rett_Intervention_and_Assessment Longitudinal (TRIAL) Database Dr Santosh 2017


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