RettUK : Key Papers

Rett UK Funded Research
Research Digest

Since 1966 when Andreas Rett first identified the symptoms of the syndrome that now bears his name, scientists from all over the world have furthered his work. These pages contain some of the key papers in the history of Rett research, recent work with CDKL5 and FOXG1 as well as social and rett related work.

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. (1999) Amir, Van den Veyver, Wan, Tran, Francke& Zoghbi^. Nature Genetics 23, 185 - 188

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. (2001) Guy, Hendrich, Holmes, Martin & Bird. Nature Genetics 27, 322 - 326

Reversal of Neurological Defects in a Mouse Model of Rett Syndrome. (2007) Guy, Gan, Selfridge, Cobb & Bird. Science 23 February 2007 Vol. 15 no. 5815, pp. 1143 - 1147